Dose-response in case-control studies.
نویسندگان
چکیده
منابع مشابه
Mutagen sensitivity exhibits a dose-response relationship in case-control studies.
We have been quantitating, as a marker of cancer susceptibility, induced chromatid breaks in lymphocyte cultures exposed to chemical mutagens. This report highlights the consistency of the results from two case-control studies, using different methods of presenting the data. In both the lung cancer case-control study, which used bleomycin, a radiomimetic agent, as the test mutagen, and the mela...
متن کاملMutagen Sensitivity Exhibits a Dose-Response Relationship in Case-Control
We have been quantitating, as a marker of cancer susceptibility, induced chromatid breaks in lymphocyte cultures exposed to chemical mutagens. This report highlights the consistency of the results from two casecontrol studies, using different methods of presenting the data. In both the lung cancer case-control study, which used bleomycin, a radiomimetic agent, as the test mutagen, and the melan...
متن کاملRobustness of design in dose–response studies
We construct experimental designs for dose–response studies. The designs are robust against possibly misspecified link functions; for this they minimize the maximum meansquared error of the estimated dose required to attain a response in 100p% of the target population. Here p might be one particular value—pD0:5 corresponds to ED50-estimation—or it might range over an interval of values of inter...
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Dose–response studies are useful in Phase II and Phase III clinical trials to evaluate efficacy and toxicity of a drug in order to determine its effective and safe ranges. A zero dose is generally included as a control against which higher doses are compared. This naturally leads to multiple comparisons. The ordered nature of doses suggests the use of stepwise multiple test procedures. The purp...
متن کاملCase-Control Studies, Inference in
Classic (or ‘‘cumulative’’) case-control sampling designs do not admit inferences about quantities of interest other than risk ratios and then only by making the rare events assumption. Probabilities, risk differences, number needed to treat, and other quantities cannot be computed without knowledge of the population incidence fraction. Similarly, density (or ‘‘risk set’’) case-control sampling...
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ژورنال
عنوان ژورنال: Journal of Epidemiology & Community Health
سال: 1980
ISSN: 0143-005X
DOI: 10.1136/jech.34.3.217